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The News summary below is based on the query - "Adipose + Derived + Cells"
 

Medical Xpress - latest medical and health news stories

Medical Xpress internet news portal provides the latest news on Health and Medicine.
  • Culprit in reducing effectiveness of insulin identified
    Scientists at Osaka University have discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduces the effectiveness of insulin in adipocytes and decreased insulin-induced glucose uptake.
  • Obesity may promote resistance to antiangiogenic therapy for breast cancer
    Obesity—which is already known to reduce survival in several types of cancer—may explain the ineffectiveness of angiogenesis inhibitors in the treatment of breast cancer. A research team led by Massachusetts General Hospital (MGH) investigators describes finding, for the first time, that obesity and obesity-related molecular factors appear to induce resistance to antiangiogenic therapy in breast cancer patients and in two mouse models of the disease. Their report in Science Translational Medicine also details specific obesity-related factors underlying that resistance and outlines potential therapeutic strategies that may overcome it.
  • Mesenchymal stem cell therapy: Holding promise for feline inflammatory diseases
    Stem cell therapy is acknowledged as having great potential for the treatment of a variety of diseases in both people and animals. The use of bone marrow-derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow- and adipose-derived stem cells are being evaluated.
  • FDA-approved clinical trial tests stem cells to heal wounds
    Sanford Health is launching its second adipose-derived stem cell clinical trial - this one to focus on non-healing leg wounds.
  • Study shows protein called 'survivin' which protects fat cells from death is at higher levels in obese people
    New research presented at this year's European Congress on Obesity (ECO) in Porto, Portugal (17-20 May) shows the obese people have higher levels of a protein called survivin, which protects fat-containing adipocyte cells in the body from being destroyed. The study was led by Dr Sonia Fernández-Veledo and Dr Joan Vendrell and is presented at ECO by Dr Miriam Ejarque, all of the Pere Virgili Institute, Rovira i Virgili University, CIBERDEM, Taragona, Spain.
  • Postbiotic could lower glucose, inflammation in obesity
    (HealthDay)—The bacterial cell wall-derived muramyl dipeptide (MDP) postbiotic lowers adipose inflammation and reduces glucose intolerance in obese mice, according to an experimental study published online April 20 in Cell Metabolism.
  • Sulforaphane, a phytochemical in broccoli sprouts, ameliorates obesity
    Sulforaphane, a phytochemical contained in broccoli sprouts at relatively high concentrations, has been known to exert effects of cancer prevention by activating a transcription factor, Nrf2 (nuclear factor (erythroid-derived 2)-like 2), which regulates the balance of oxidation/reduction in the cell, and by enhancing the anti-oxidation ability of the body and detoxication of chemical compounds. On the other hand, when the balance of oxidation/reduction is deteriorated due to obesity, it has been known to lead to pathogenesis of various diseases. The effects of sulforaphane on obesity were, however, unclear.
  • Making metabolically active brown fat from white fat-derived stem cells
    Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells (ASCs). The study describes a method to produce brown fat tissue, which exists in only small amounts in adults, and is published in Tissue Engineering, Part A.
  • Study shows adipose stem cells may be the cell of choice for therapeutic applications
    An international team of researchers, funded by Morris Animal Foundation, has shown that adipose (fat) stem cells might be the preferred stem cell type for use in canine therapeutic applications, including orthopedic diseases and injury.
  • Stem cells collected from fat may have use in anti-aging treatments
    Adult stem cells collected directly from human fat are more stable than other cells - such as fibroblasts from the skin - and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. They made the discovery after developing a new model to study chronological aging of these cells. They published their findings this month in the journal Stem Cells.

 

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