What are Mesenchymal Stem Cells?
Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and differentiation with a broad tissue distribution. Initially described in bone marrow, MSCs have the capacity to differentiate into mesoderm- and nonmesoderm-derived tissues. The endogenous role for MSCs is maintenance of stem cell niches (classically the hematopoietic), and as such, MSCs participate in organ homeostasis, wound healing, and successful aging. From a therapeutic perspective, and facilitated by the ease of preparation and immunologic privilege, MSCs are emerging as an extremely promising therapeutic agent for tissue regeneration. Studies in animal models of myocardial infarction have demonstrated the ability of transplanted MSCs to engraft and differentiate into cardiomyocytes and vasculature cells, recruit endogenous cardiac stem cells, and secrete a wide array of paracrine factors.
Together, these properties can be harnessed to both prevent and reverse remodeling in the ischemically injured ventricle. In proof-of-concept and phase I clinical trials, MSC therapy improved left ventricular function, induced reverse remodeling, and decreased scar size.
The above is a "careful" assessment by Joshua Hare- cardiologist, but despite thousands of studies "the medical establishment" is not yet totally convinced. The image you see, is what has been proven to happen upon injury by the godfather of MSCs- Arnold Caplan-i.e. activation of MSC precursers or pericytes from the outer walls of arteries to "come to the rescue" after injury and at the same time building a wall around the area to prevent run-a-way inflammation and attacks by own T-cells.
MSCs are because of the above fact (lined at the outer walls of arteries) so relevant to Fat Cells- since adipose tissue is a highly vascularized tissue, hence contains so many MSC precursers.
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The NewsmanGlobal Mesenchymal Stem Cells Market Overview 2018- STEMCELL Technologies, Biological Industries, Mesoblast
The report on the “Mesenchymal Stem Cells market“offers elaborated knowledge on the Mesenchymal Stem Cells market. parts like dominating firms, classification, size, business atmosphere, SWOT analysis, and most effectual trends within the business area ...
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Pain News Network
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Global Mesenchymal Stem Cells Market 2018 – Lonza, Thermo Fishe, Bio-Techne, ATCC, MilliporeSigma, PromoCell...
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https://ryortho.com/ (press release)Making Cell-Based Cartilage Production Scalable
https://ryortho.com/ (press release)
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