What are Mesenchymal Stem Cells?
Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and differentiation with a broad tissue distribution. Initially described in bone marrow, MSCs have the capacity to differentiate into mesoderm- and nonmesoderm-derived tissues. The endogenous role for MSCs is maintenance of stem cell niches (classically the hematopoietic), and as such, MSCs participate in organ homeostasis, wound healing, and successful aging. From a therapeutic perspective, and facilitated by the ease of preparation and immunologic privilege, MSCs are emerging as an extremely promising therapeutic agent for tissue regeneration. Studies in animal models of myocardial infarction have demonstrated the ability of transplanted MSCs to engraft and differentiate into cardiomyocytes and vasculature cells, recruit endogenous cardiac stem cells, and secrete a wide array of paracrine factors.
Together, these properties can be harnessed to both prevent and reverse remodeling in the ischemically injured ventricle. In proof-of-concept and phase I clinical trials, MSC therapy improved left ventricular function, induced reverse remodeling, and decreased scar size.
The above is a "careful" assessment by Joshua Hare- cardiologist, but despite thousands of studies "the medical establishment" is not yet totally convinced. The image you see, is what has been proven to happen upon injury by the godfather of MSCs- Arnold Caplan-i.e. activation of MSC precursers or pericytes from the outer walls of arteries to "come to the rescue" after injury and at the same time building a wall around the area to prevent run-a-way inflammation and attacks by own T-cells.
MSCs are because of the above fact (lined at the outer walls of arteries) so relevant to Fat Cells- since adipose tissue is a highly vascularized tissue, hence contains so many MSC precursers.
The effects of grafted mesenchymal stem cells labeled with iron oxide or cobalt-zinc-iron nanoparticles on the...
Dove Medical Press
Introduction: Rat mesenchymal stem cells (rMSCs) labeled with 1) poly-l-lysine-coated superparamagnetic iron oxide nanoparticles or 2) silica-coated cobalt-zinc-iron nanoparticles were implanted into the left brain hemisphere of rats, to assess their ...
Dove Medical PressBone marrow mesenchymal stem cell repair of cyclophosphamide-induced ovarian insufficiency in a mouse model
Dove Medical Press
Objective: Attempting in vivo healing of cyclophosphamide-induced ovarian insufficiency in a mouse model using bone marrow mesenchymal stem cells (BMMSCs). Methods: Female BALB/c white mice were used to prepare a model for premature ovarian ...
Creative Medical Technology Holdings Develops Platform Aimed at Augmenting All Mesenchymal Stem Cell Therapies...
PR Newswire (press release)
PHOENIX, June 7, 2017 /PRNewswire/ -- Creative Medical Technology Holdings, Inc. (OTCQB:CELZ) announced filing of a patent application covering synergy between intradiscal stem cell injection subsequent to stimulation of perispinal angiogenesis.
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AZoMGuide to Determining Viability and Concentration of Stem Cells Grown on Microcarriers
Counting mononuclear cells including adipose-derived MSC in the stromal vascular fraction. (A) The stromal vascular fraction contains beside MSC, preadipocytes, endothelial cells and ...
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ALS News TodayIsrael's BrainStorm Receives $2.1 Million Grant to Support Development of Stem-Cell Therapy NurOwn to Treat ALS
ALS News Today
NurOwn was developed by Tel Aviv University professors Dani Offen and the late Eldad Melamed. NurOwn builds on research developing mesenchymal stem cells (MSCs) as a treatment for human diseases. MSCs are multipotent precursor cells that exist in ...
PR Web (press release)Provia Labs Launches Library of Mesenchymal Stem Cell Research Samples Sourced from Dental, Adipose, Placental...
PR Web (press release)
Provia Laboratories LLC (Provia), a leader in cGMP autologous cell and tissue services, announced the launch of a comprehensive library of stem cell material available for researchers. The library includes ready to ship mesenchymal stem cells (MSCs ...
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Vail Daily NewsAsk a Vail Sports Doc: The future of regenerative sports medicine
Vail Daily News
Researchers have performed throughout 500 clinical trials evaluating mesenchymal stem cells and there have been more than 180 trials evaluating platelet rich plasma, which is a testimony to the level of interest in biologics and the hope of treating or ...
Stem cells might not be a good option for your kid's sports injury
Over the last several years, we have seen a dramatic increase in interest in regenerative medicine, especially the use of PRP and mesenchymal stem cells to help athletes return to their sport after injury. Yet many patients and caregivers struggle to ...
Trialling stem cell treatment for vascular disease
In a study of mesenchymal stem cells (MSCs) to treat atherosclerotic renovascular disease, 28 patients received standard medical treatment, 14 of whom also received a single infusion of MSCs. Patients who received MSCs showed no adverse clinical effects.
Cynata Therapeutics Files New Patent Application for Cymerus™ Stem Cell Technology in Oncology
Cymerus overcomes critical issues in the production of therapeutic mesenchymal stem cells (MSCs) by enabling the economical manufacture of commercial-scale MSCs, independent of multi-donor limitations. Cymerus' novel approach utilises induced ...
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