What are Mesenchymal Stem Cells?
Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and differentiation with a broad tissue distribution. Initially described in bone marrow, MSCs have the capacity to differentiate into mesoderm- and nonmesoderm-derived tissues. The endogenous role for MSCs is maintenance of stem cell niches (classically the hematopoietic), and as such, MSCs participate in organ homeostasis, wound healing, and successful aging. From a therapeutic perspective, and facilitated by the ease of preparation and immunologic privilege, MSCs are emerging as an extremely promising therapeutic agent for tissue regeneration. Studies in animal models of myocardial infarction have demonstrated the ability of transplanted MSCs to engraft and differentiate into cardiomyocytes and vasculature cells, recruit endogenous cardiac stem cells, and secrete a wide array of paracrine factors.
Together, these properties can be harnessed to both prevent and reverse remodeling in the ischemically injured ventricle. In proof-of-concept and phase I clinical trials, MSC therapy improved left ventricular function, induced reverse remodeling, and decreased scar size.
The above is a "careful" assessment by Joshua Hare- cardiologist, but despite thousands of studies "the medical establishment" is not yet totally convinced. The image you see, is what has been proven to happen upon injury by the godfather of MSCs- Arnold Caplan-i.e. activation of MSC precursers or pericytes from the outer walls of arteries to "come to the rescue" after injury and at the same time building a wall around the area to prevent run-a-way inflammation and attacks by own T-cells.
MSCs are because of the above fact (lined at the outer walls of arteries) so relevant to Fat Cells- since adipose tissue is a highly vascularized tissue, hence contains so many MSC precursers.
Multiple sclerosis: Oligodendrocytes from stem cells
EurekAlert (press release)
Janusz Jadasz - the first author of the study published in the renowned journal GLIA - revealed together with his colleagues that the interaction and communication of two different stem cell types, mesenchymal stem cells originating from bone, the ...
Evaluating the biological risk of functionalized multiwalled carbon nanotubes and functionalized oxygen-doped...
Dove Medical Press
In this study, we determine whether functionalized multiwalled CNTs (fMWCNTs) and functionalized oxygen-doped multiwalled CNTs (fCOxs) have toxic effects on rat mesenchymal stem cells (MSCs) in vitro by analyzing morphology and cell proliferation and, ...
Autologous stem cell transplantation may be feasible for advanced keratoconus
The research has focused on mesenchymal stem cells from different ocular and non-ocular tissues for their ability to differentiate into keratocytes in vivo. Among them, human adipose tissue has demonstrated to be ideal as a source of autologous stem ...
Asia Regulatory Roundup: India Tightens Stem Cell Guidelines (17 September 2017)
“It is imperative that the [government] should impose a strict ban on usage of these [mesenchymal stem cells]s for treatments today and ensure compliance but not restrict preservation for the future,” Mayur Abhaya, the CEO of LifeCell, said. “I'm sure ...
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Evaluation of synergistic osteogenesis between icariin and BMP2 through a micro/meso hierarchical porous delivery...
Dove Medical Press
... chain reaction analysis indicated that the SFBMP2/SBA15IC scaffold induced a significantly higher increase in the RUNX2, ALP, COL I, and OCN expression levels of cocultured bone marrow mesenchymal stem cells than other payload composite scaffolds.
IBD News TodayMesenchymal Stem Cell Infusion a Possible Therapy for Crohn's Fistulas, Review Study Suggests
IBD News Today
While current treatments for fistulas in Crohn's disease patients have often led to unsatisfactory results, new stem cell-based therapies, specifically mesenchymal stem cells (MSCs), have shown great potential, a review analysis has found. The study ...
Longeveron Pioneering Development of Stem Cell Therapies for...
MIAMI, Oct. 17, 2017 /PRNewswire/ -- Longeveron LLC, a leading life sciences company developing innovative therapies for age-related diseases, announced ...
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Will stem cell therapy help with arthritis?
Palm Beach Post
The most common type of stem cells used in therapy are mesenchymal stem cells. Sometimes called adult stem cells, mesenchymal stem cells have the potential to develop into musculoskeletal cells, such as fat, bone, or cartilage cells. Many researchers ...
Multiple Sclerosis News TodayImStem, UConn Obtain US Patent for Mesenchymal Stem Cell Technology to Treat MS, Other Diseases
Multiple Sclerosis News Today
The U.S. Patent and Trademark Office has issued a patent for human embryonic stem cells derived mesenchymal stem cells, called hES-T-MSC or T-MSC, and for their method of production. This newly patented technology was developed by ImStem ...
TechnoPOW (blog)Mesenchymal Stem Cells Market by Asia-Pacific Briefing 2017 to 2022
Asia-Pacific Mesenchymal Stem Cells Market by Manufacturers, Regions, Type and Application, Forecast to 2022 provides a unique tool for evaluating the ...
Mesenchymal Stem Cells Market Size, Overview, and Forecast 2022
TEDCO awards $1 million for stem cell projects
Maryland Daily Record
Global Hematopoietic Stem Cells Transplantation (HSCT) Market 2017-2021: Growing Demand for Personalized...
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