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Medical Xpress Mesenchymal Cells News Query

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The News summary below is based on the query - "Mesenchymal + Cells"
 

Medical Xpress - latest medical and health news stories

Medical Xpress internet news portal provides the latest news on Health and Medicine.
  • Study identifies stem cell that gives rise to new bone and cartilage in humans
    A decade-long effort led by Stanford University School of Medicine scientists has been rewarded with the identification of the human skeletal stem cell.
  • Small molecule plays big role in weaker bones as we age
    With age, expression of a small molecule that can silence others goes way up while a key signaling molecule that helps stem cells make healthy bone goes down, scientists report.
  • Factor to boost MSCs and collagen II activity in intervertebral disc degeneration identified
    A new study has demonstrated the tissue regenerative potential of a chemoattractant delivery system that can draw mesenchymal stem cells (MSCs) to the site of intervertebral disc (IVD) degeneration. The study, carried out in a cow model of IVD degeneration, not only showed the recruitment of regenerative cells, but also reported increased collagen production, as described in an article published in Tissue Engineering Part A.
  • Discovery could lead to higher immunotherapy response rates for bladder cancer patients
    Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.
  • The art of building bone
    Cell differentiation is a widely studied phenomenon forming the basis of all developmental processes including fetal growth and bone fracture healing. A series of recent studies indicates the emerging role of chondrocyte-to-osteoblast transdifferentiation during bone tissue formation, known as endochondral ossification (replacing cartilage with bone).
  • Modifying the major model of a modern major mouse model
    If a new anti-cancer drug shows promise in a Petri dish, often the next step is to test the drug's effect in mice. This system tends to work well with drugs that directly target cancer, but breaks down with immunotherapies. That's because tumors from human cancer samples can only grow in mice with suppressed immune systems. Immunotherapies activate the immune system against cancer. And in a mouse model in which the immune system has been suppressed, there is no immune system to activate against cancer.
  • Bioprinting bone substitute materials with cell-laden bioinks
    Bone tissue engineering (BTE) is a developing field in materials science and bioengineering, in which researchers aim to engineer an ideal, bioinspired material to promote assisted bone repair. Since experimental strategies are yet to translate from the laboratory bench to clinical practice in orthopedics, the research field combines cutting-edge technologies for exciting new approaches in bone substitute materials development. The interplay of cells, proteins, biological components and biomaterials during biofabrication in the lab can assist the manufacture of biological building blocks at the industrial scale for applications in regenerative medicine.
  • Bioengineered tooth replacement opens doors to new therapies
    Tooth loss is a significant health issue currently affecting millions of people worldwide. While artificial dental implants are the existing standard tooth replacement therapy, they do not exhibit many properties of natural teeth and can be associated with complications leading to implant failure. Two articles published in the September 2018 issue of the Journal of Dental Research share recent advances in bioengineering teeth.
  • Platelet-rich plasma does not promote stem cell-mediated cartilage repair
    Platelet-rich plasma (PRP) is believed to provide pain relief and help improve joint function in degenerative joint disease, but a new study has shown that it does not act by promoting stem cell proliferation or enhance the cartilage formation capabilities of mesenchymal stem cells (MSCs). The effects of PRP treatment on cartilage formation and chondrogenesis in the presence of adult human MSCs derived from two different sources are reported in the study published in Tissue Engineering, Part A.
  • Researchers find estrogen receptor gene fusions are a cause of breast cancer metastasis and lethal drug resistance
    Estrogen receptor positive (ER+) breast cancer is the most common type of breast cancer, but resistance to therapy is common and eventual development of metastatic disease is a leading cause of death. In new research published in Cell Reports, researchers from Baylor College of Medicine and Washington University in St. Louis identify estrogen receptor alpha gene (ESR1) translocation events that drive not only therapeutic resistance, but also trigger ER+ breast cancer cells to metastasize.
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